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Invitrogen
CAD Polyclonal Antibody
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Product Details
PA5-67042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CAD. Recombinant protein control fragment (Product #RP-105473).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SHLPIVAHAEQ QTVAAVLMVA QLTQRSVHIC HVARKEEILL IKAAKARGLP VTCEVAPHHL FLSHDDLERL GPGKGEVRPE LGSRQDVEAL WENMAVIDCF ASDHAPHTLE EKCGSR
Highest antigen sequence identity to the following orthologs - mouse 89%, rat 89%.
Target Information
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAD trifunctional protein; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; Multifunctional protein CAD
Gene Aliases: CAD; CDG1Z
UniProt ID: (Human) P27708
Entrez Gene ID: (Human) 790
aspartate carbamoyltransferase activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
dihydroorotase activity
protein kinase activity
ATP binding
zinc ion binding
enzyme binding
identical protein binding
aspartate binding
hydrolase
ligase
urea cycle
liver development
'de novo' pyrimidine nucleobase biosynthetic process
UTP biosynthetic process
arginine biosynthetic process
glutamine metabolic process
heart development
female pregnancy
lactation
response to amine
drug metabolic process
peptidyl-threonine phosphorylation
response to caffeine
organ regeneration
response to testosterone
cellular response to drug
'de novo' UMP biosynthetic process
pyrimidine nucleoside biosynthetic process
protein autophosphorylation
response to cortisol
cellular response to epidermal growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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