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Invitrogen
DAGLB Polyclonal Antibody
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Product Details
PA5-67047
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human DAGLB. Recombinant protein control fragment (Product #RP-105476).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVALDHRKESV VVAVRGTMSL QDVLTDLSAE SEVLDVECEV QDRLAHKGIS QAARYVYQRL INDGILSQAF SIA
Highest antigen sequence identity to the following orthologs - mouse 78%, rat 80%.
Target Information
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAGL-beta; DGL-beta; Diacylglycerol lipase-beta; KCCR13L; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta; unnamed protein product
Gene Aliases: DAGLB; DAGLBETA; KCCR13L
UniProt ID: (Human) Q8NCG7
Entrez Gene ID: (Human) 221955
prostaglandin biosynthetic process
lipid metabolic process
monoacylglycerol biosynthetic process
icosanoid metabolic process
neuroblast proliferation
positive regulation of triglyceride catabolic process
lipid catabolic process
arachidonic acid metabolic process
neurogenesis
diacylglycerol catabolic process
regulation of inflammatory response
cannabinoid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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