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Invitrogen
TSC22D1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-67456
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human TSC22. Recombinant protein control fragment (Product #RP-108113).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QYGQQQPMVST QMAPGHVKSV TQNPASEYVQ QQPILQTAMS SGQPSSAGVG AGTTVIPVAQ PQGIQLPVQP TAVPAQPAGA SVQP
Highest antigen sequence identity to the following orthologs - mouse 74%, rat 78%.
Target Information
TSC22 domain family protein, or TSC22, is a transcription factor that belongs to the large family of early response genes. This transcriptional repressor is known to act on the C-type natriuretic peptide (CNP) promoter. TSC22 belongs to the TSC-22/Dip/Bun family and is an intracellular protein that may be found in the cytoplasm or nucleus. This transcription factor is known to regulate cell growth, differentiation and cell death and is involved in modulating the transcriptional activity of Smad3 and Smad4. This protein is ubiquitously expressed in most tissues and widely in both fetal and adult tissues. It is generally expressed in aortic endothelial cells, and induced by cytokines, including TGFB. These proteins may be possible therapeutic targets of leukemia and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cerebral protein 2; regulatory protein TSC-22; RP11-269C23.2; TGFB-stimulated clone 22 homolog; TGFbeta-stimulated clone 22; transcriptional regulator TSC-22; transforming growth factor beta-1-induced transcript 4 protein; transforming growth factor beta-stimulated protein TSC-22; TSC22; unnamed protein product
Gene Aliases: HUCEP-2; Ptg-2; TGFB1I4; TSC22
UniProt ID: (Human) Q15714
Entrez Gene ID: (Human) 8848
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of programmed cell death
positive regulation of transcription, DNA-templated
negative regulation of hematopoietic stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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