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Invitrogen
Thymidine Phosphorylase Polyclonal Antibody
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Product Details
PA5-81876
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TYMP. Recombinant protein control fragment (Product #RP-91382).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG VGDKVSLVLA PALAACGCKV PMISG
Highest antigen sequence indentity to the following orthologs: Mouse - 77%, Rat - 78%.
Target Information
A platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gliostatin; OTTHUMP00000196767; OTTHUMP00000196770; PD TP; PD-ECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; unnamed protein product
Gene Aliases: ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PDECGF; TP; TYMP
UniProt ID: (Human) P19971
Entrez Gene ID: (Human) 1890
mitochondrial genome maintenance
angiogenesis
pyrimidine nucleobase metabolic process
pyrimidine nucleoside metabolic process
chemotaxis
signal transduction
cell differentiation
regulation of myelination
dTMP catabolic process
regulation of transmission of nerve impulse
nucleobase-containing small molecule metabolic process
pyrimidine-containing compound metabolic process
carbohydrate derivative metabolic process
regulation of gastric motility
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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