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Invitrogen
SH3BP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-81891
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SH3BP1. Recombinant protein control fragment (Product #RP-91341).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ENLSNLRYLM KFLARLAEEQ EVNKMTPSNI AIVLGPNLLW PPEKEGDQAQ LDAASVSSIQ VVGVVEALIQ SADTLFPGDI NFNVSGLFSA VTLQDTVSDR LASEELPSTA VPTPATTPAP APAPAPAPAP ALASAATKER TESEVPP
Highest antigen sequence indentity to the following orthologs: Rat - 74%, Mouse - 75%.
Target Information
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3BP-1; OTTHUMP00000028981; SH3BP1; unnamed protein product
Gene Aliases: ARHGAP43
UniProt ID: (Human) Q9Y3L3
Entrez Gene ID: (Human) 23616
phagocytosis, engulfment
actin filament organization
signal transduction
cell migration
regulation of actin filament depolymerization
regulation of actin cytoskeleton organization
cell junction assembly
regulation of Rac protein signal transduction
regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
establishment of epithelial cell apical/basal polarity
regulation of small GTPase mediated signal transduction
negative regulation of small GTPase mediated signal transduction
semaphorin-plexin signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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