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Invitrogen
Thioredoxin 2 Polyclonal Antibody
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Product Details
PA5-81912
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TXN2. Recombinant protein control fragment (Product #RP-91356).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTSRALQTPQ CSPGGLTVTP NPARTIYTTR ISLTTFNIQD GPDFQDRVVN SETPVVVDFH AQWCGPCKIL GPRLEKMVAK QHGKVVMAKV DIDDHTDLAI EYEVSAVPTV LAMKNGDVVD KFVGIKDEDQ LEAFLKKL
Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 91%.
Target Information
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitochondrial thioredoxin; MTRX; Thioredoxin, mitochondrial; Thioredoxin-2; Thioredoxin2; TRX-2
Gene Aliases: COXPD29; MT-TRX; MTRX; TRX2; TXN2
UniProt ID: (Human) Q99757
Entrez Gene ID: (Human) 25828
sulfate assimilation
response to reactive oxygen species
response to hypoxia
protein folding
glycerol ether metabolic process
response to nutrient
response to hormone
response to glucose
response to organic cyclic compound
cellular response to nutrient levels
cellular response to oxidative stress
response to drug
cell redox homeostasis
response to axon injury
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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