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Invitrogen
IKK beta Polyclonal Antibody
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Product Details
PA5-81927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human IKBKB. Recombinant protein control fragment (Product #RP-99395).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PNGCFKALDD ILNLKLVHIL NMVTGTIHTY PVTEDESLQS LKARIQQDTG IPEEDQELLQ EAGLALIPDK PATQCISDGK LNEGHTLDMD LVFLFDNSKI TYETQISPRP QPESVSCILQ EPKRNLAFFQ LRKVWGQVWH
Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 87%.
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex. Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; nuclear factor kappa B kinase subunit beta; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB; unnamed protein product
Gene Aliases: IKBKB; IKK-2; IKK-beta; IKK2; IKKB; IMD15; IMD15A; IMD15B; NFKBIKB
UniProt ID: (Human) O14920
Entrez Gene ID: (Human) 3551
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
kinase activity
transferase activity
protein kinase binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
protein serine kinase activity
transferrin receptor binding
protein polyubiquitination
pattern recognition receptor signaling pathway
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
MyD88-dependent toll-like receptor signaling pathway
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
inflammatory response
I-kappaB kinase/NF-kappaB signaling
response to virus
positive regulation of macromolecule metabolic process
regulation of tumor necrosis factor-mediated signaling pathway
peptidyl-serine phosphorylation
signal transduction involved in regulation of gene expression
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
toll-like receptor 3 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
protein maturation
interleukin-1-mediated signaling pathway
cellular response to tumor necrosis factor
protein localization to plasma membrane
negative regulation of cytokine production involved in inflammatory response
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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