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Invitrogen
FADD Polyclonal Antibody
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Product Details
PA5-81943
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FADD. Recombinant protein control fragment (Product #RP-95401).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTELKFLCLG RVGKRKLERV QSGLDLFSML LEQNDLEPGH TELLRELLAS LRRHDLLRRV DDFEAGAAAG AAPGEEDLCA AFNVICDNVG KDWRRLARQL KVSDTKIDSI EDRYPRNLTE RVRESLRIWK N
Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 75%.
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FADD; Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; unnamed protein product
Gene Aliases: FADD; GIG3; IMD90; MORT1
UniProt ID: (Human) Q13158
Entrez Gene ID: (Human) 8772
protease binding
death receptor binding
tumor necrosis factor receptor binding
protein binding
protein binding, bridging
tumor necrosis factor receptor superfamily binding
receptor serine/threonine kinase binding
signaling adaptor activity
death effector domain binding
identical protein binding
macromolecular complex binding
caspase binding
positive regulation of cytokine production
kidney development
positive regulation of T cell mediated cytotoxicity
immune system process
positive regulation of adaptive immune response
apoptotic process
signal transduction
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of interferon-gamma production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
T cell differentiation in thymus
TRAIL-activated apoptotic signaling pathway
positive regulation of activated T cell proliferation
response to cocaine
regulation of apoptotic process
T cell homeostasis
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of innate immune response
positive regulation of macrophage differentiation
positive regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
behavioral response to cocaine
lymph node development
spleen development
thymus development
positive regulation of immune response
defense response to virus
positive regulation of type I interferon-mediated signaling pathway
regulation of necroptotic process
negative regulation of necroptotic process
negative regulation of activation-induced cell death of T cells
cellular response to mechanical stimulus
death-inducing signaling complex assembly
motor neuron apoptotic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
necroptotic signaling pathway
defense response to other organism
positive regulation of execution phase of apoptosis
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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