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Invitrogen
Laminin beta-2 Polyclonal Antibody
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Product Details
PA5-81986
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LAMB2. Recombinant protein control fragment (Product #RP-101042).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DLTDVQDENF NANHALSGLE RDRLALNLTL RQLDQHLDLL KHSNFLGAYD SIRHAHSQSA EAERRANTSA LAVPSPVSNS ASARHRTEAL MDAQKEDFNS KHMANQRALG KLSAHTHTLS LTDINELVCG APG
Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 82%.
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Laminin B1s chain; laminin S; Laminin subunit beta-2; laminin, beta 2 (laminin S); Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-LAM beta; S-laminin subunit beta; unnamed protein product
Gene Aliases: LAMB2; LAMS; NPHS5; PIERS
UniProt ID: (Human) P55268
Entrez Gene ID: (Human) 3913
cell morphogenesis
cell adhesion
axon guidance
neuromuscular junction development
visual perception
astrocyte development
Schwann cell development
neuron projection development
positive regulation of cell adhesion
axon extension involved in regeneration
synapse organization
positive regulation of muscle cell differentiation
retina development in camera-type eye
metanephric glomerular visceral epithelial cell development
metanephric glomerular basement membrane development
regulation of basement membrane organization
positive regulation of integrin-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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