Search
Invitrogen
Laminin gamma-1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 7
Laminin gamma-1 Antibody (PA5-81991) in IHC (P)
Immunohistochemistry analysis of Laminin gamma-1 in human cerebral cortex, kidney, placenta and tonsil. Samples were incubated with Laminin gamma-1 polyclonal antibody (Product # PA5-81991). Shows similar protein distribution across tissues to independent Laminin gamma-1 antibody (Product # PA5-81992) (B).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-81991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LAMC1. Recombinant protein control fragment (Product #RP-101883).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ECREGFVGNR CDQCEENYFY NRSWPGCQEC PACYRLVKDK VADHRVKLQE LESLIANLGT GDEMVTDQAF EDRLKEAERE VMDLLREAQD VKDVDQNLMD RLQRVNNTLS SQISRLQNIR NTIEETGNLA EQARAHVENT ERLIEIASR
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: laminin B2 chain; laminin B2 precursor; laminin, gamma 1 (formerly LAMB2); laminin-10 subunit gamma; laminin-11 subunit gamma; laminin-2 subunit gamma; laminin-3 subunit gamma; laminin-4 subunit gamma; laminin-6 subunit gamma; laminin-7 subunit gamma; laminin-8 subunit gamma; laminin-9 subunit gamma; S-LAM gamma; S-laminin subunit gamma
Gene Aliases: LAMB2
UniProt ID: (Human) P11047
Entrez Gene ID: (Human) 3915
cell adhesion
signal transduction
endoderm development
tissue development
cell migration
extracellular matrix disassembly
regulation of cell adhesion
regulation of cell migration
hemidesmosome assembly
substrate adhesion-dependent cell spreading
maintenance of blood-brain barrier
positive regulation of cell adhesion
regulation of embryonic development
positive regulation of epithelial cell proliferation
positive regulation of muscle cell differentiation
protein-containing complex assembly
regulation of basement membrane organization
positive regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of integrin-mediated signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support