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Invitrogen
SOX6 Polyclonal Antibody
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Product Details
PA5-81994
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SOX6. Recombinant protein control fragment (Product #RP-102022).
Conjugate
Form
Liquid
Concentration
0.09 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TYKPGDNYPV QFIPSTMAAA AASGLSPLQL QQLYAAQLAS MQVSPGAKMP STPQPPNTAG TVSPTGIKNE KRGTSPVTQV KDEAAAQPLN LSSRPKTAEP VKSPTS
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.
Target Information
The SOX6 gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which are known to play vital roles in the regulation of developmental processes and cell fate determination. SOX6, along with its close relatives SOX5 and SOX13, constitutes the SOXD subfamily, which is involved in the regulation of the development of the central nervous system, skeletal system, and cartilage. It functions by binding to specific DNA sequences and modulating the expression of target genes necessary for these developmental processes. SOX6 has been implicated in various functions, such as promoting cartilage formation by acting in conjunction with SOX9 to drive chondrogenesis. In adult neural stem cells, SOX6 is essential for the activation of radial glial-like cells and the generation of new neurons, emphasizing its role in both embryonic development and adult tissue maintenance. The dysregulation of SOX6 has been associated with developmental disorders and its potential involvement in pathologies like cancer, where it influences cell differentiation and proliferation pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 6; SRY box 6; SRY-box containing gene 6; Transcription factor SOX-6
Gene Aliases: HSSOX6; SOX6; SOXD
UniProt ID: (Human) Q9H0I8
Entrez Gene ID: (Human) 55553
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
muscle organ development
post-embryonic development
gene silencing
oligodendrocyte cell fate specification
positive regulation of chondrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
astrocyte differentiation
erythrocyte development
cartilage development
cardiac muscle cell differentiation
positive regulation of cartilage development
cellular response to transforming growth factor beta stimulus
negative regulation of cardiac muscle cell differentiation
positive regulation of mesenchymal stem cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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