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Invitrogen
FGR Polyclonal Antibody
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Product Details
PA5-81997
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FGR. Recombinant protein control fragment (Product #RP-95911).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VFCKKLEPVA TAKEDAGLEG DFRSYGAADH YGPDPTKARP ASSFAHIPNY SNFSSQAINP GFLDSGTIRG VSGIGVTLFI ALYDYEARTE DDLTFTKGEK FHILNNTEGD WWEARSLSSG KTGCIPSNYV APVDSIQAEE WYFGKIG
Highest antigen sequence indentity to the following orthologs: Mouse - 68%, Rat - 71%.
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-fgr protooncogene; c-src-2 proto-oncogene; EC 2.7.10.2; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR protein; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55-c-fgr protein; p55-Fgr; p58-Fgr; p58c-Fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; Tyrosine-protein kinase Fgr; unnamed protein product; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Gene Aliases: c-fgr; c-src2; FGR; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2
UniProt ID: (Human) P09769
Entrez Gene ID: (Human) 2268
nucleotide binding
phosphotyrosine binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
immunoglobulin receptor binding
Fc-gamma receptor I complex binding
positive regulation of cytokine production
immune system process
immune response-regulating cell surface receptor signaling pathway
negative regulation of inflammatory response to antigenic stimulus
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
response to virus
peptidyl-tyrosine phosphorylation
cell differentiation
bone mineralization
positive regulation of cell migration
negative regulation of natural killer cell activation
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of mast cell degranulation
innate immune response
regulation of innate immune response
regulation of protein kinase activity
protein autophosphorylation
skeletal system morphogenesis
regulation of phagocytosis
defense response to Gram-positive bacterium
positive regulation of protein kinase B signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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