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Invitrogen
RNaseL Polyclonal Antibody
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Product Details
PA5-82024
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNASEL. Recombinant protein control fragment (Product #RP-102053).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HGAKEDFHPP AEDWKPQSSH WGAALKDLHR IYRPMIGKLK FFIDEKYKIA DTSEGGIYLG FYEKQEVAVK TFCEGSPRAQ REVSCLQSSR ENSHLVTFYG SESHRGHLFV CVTLCEQTLE ACLDVHRGED VENEEDEFAR NVLSSI
Highest antigen sequence indentity to the following orthologs: Mouse - 58%, Rat - 58%.
Target Information
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L
Gene Aliases: PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823
Entrez Gene ID: (Human) 6041
rRNA processing
mRNA processing
protein phosphorylation
regulation of mRNA stability
negative regulation of viral genome replication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
transmembrane transport
type I interferon signaling pathway
RNA phosphodiester bond hydrolysis, endonucleolytic
positive regulation of glucose import in response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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