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Invitrogen
Biglycan Polyclonal Antibody
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Product Details
PA5-82066
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BGN. Recombinant protein control fragment (Product #RP-92253).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGFWDFTLDD GPFMMNDEEA SGADTSGVLD PDSVTPTYSA MCPFGCHCHL RVVQCSDLGL KSVPKEISPD TTLLDLQNND ISELRKDDFK GLQHLYALVL VNNKISKIHE KAFSPLRKLQ KLYISKNHLV EIPPNLPSSL
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 94%.
Target Information
BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transferring growth factor-beta. It may promote neuronal survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Biglycan; Bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; PG S1; PG-S1; small leucine-rich protein 1A
Gene Aliases: BGN; DSPG1; PG-S1; PGI; SLRR1A
UniProt ID: (Human) P21810
Entrez Gene ID: (Human) 633
blood vessel remodeling
negative regulation of protein kinase activity
biological_process
cytokine-mediated signaling pathway
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
extracellular matrix organization
glycosaminoglycan metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
dermatan sulfate biosynthetic process
negative regulation of JAK-STAT cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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