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Invitrogen
PTK7 Polyclonal Antibody
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Product Details
PA5-82070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTK7. Recombinant protein control fragment (Product #RP-101056).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TAIVFIKQPS SQDALQGRRA LLRCEVEAPG PVHVYWLLDG APVQDTERRF AQGSSLSFAA VDRLQDSGTF QCVARDDVTG EEARSANASF NIKWIEAGPV VLKHPASEAE IQPQTQVTLR CHIDGHPRPT YQWFR
Highest antigen sequence indentity to the following orthologs: Rat - 29%, Mouse - 93%.
Target Information
CCK4 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine kinase 7; receptor protein tyrosine kinase-like molecule; splice variant 1; splice variant 2; splice variant 3; splice variant 4; splice variant 5; Tyrosine-protein kinase-like 7; unnamed protein product
Gene Aliases: CCK-4; CCK4; PTK7
UniProt ID: (Human) Q13308
Entrez Gene ID: (Human) 5754
establishment of planar polarity
kidney development
neural tube closure
ventricular septum development
axis elongation
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
axon guidance
heart development
positive regulation of neuron projection development
Wnt signaling pathway
cell migration
actin cytoskeleton organization
wound healing
establishment of epithelial cell apical/basal polarity
synapse organization
convergent extension
lung-associated mesenchyme development
regulation of canonical Wnt signaling pathway
coronary vasculature development
cellular response to retinoic acid
cochlea morphogenesis
positive regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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