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Invitrogen
PBX1 Polyclonal Antibody
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Product Details
PA5-82100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PBX1. Recombinant protein control fragment (Product #RP-101910).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PRLMHSHAGV GMAGHPGLSQ HLQDGAGGTE GEGGRKQDIG DILQQIMTIT DQSLDEAQAR KHALNCHRMK PALFNVLCEI KEKTVLSIRG AQEEEPTDPQ LMRLDNMLLA EGV
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 77%.
Target Information
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; homeobox-containing protein; MGC126627; OTTHUMP00000032205; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; unnamed protein product
Gene Aliases: 2310056B04Rik; CAKUHED; D230003C07Rik; Pbx-1; PBX1; PRL
UniProt ID: (Human) P40424, (Mouse) P41778
Entrez Gene ID: (Human) 5087, (Mouse) 18514, (Rat) 304947
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor binding
protein heterodimerization activity
molecular_function
homeodomain transcription factor
G2/M transition of mitotic cell cycle
eye development
urogenital system development
branching involved in ureteric bud morphogenesis
natural killer cell differentiation
regulation of transcription, DNA-templated
steroid biosynthetic process
brain development
sex differentiation
cell proliferation
organ morphogenesis
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of G2/M transition of mitotic cell cycle
cell differentiation
regulation of ossification
adrenal gland development
embryonic limb morphogenesis
embryonic hemopoiesis
regulation of cell proliferation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
spleen development
thymus development
embryonic organ development
neuron development
embryonic skeletal system development
stem cell proliferation
positive regulation of stem cell proliferation
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
positive regulation of cell proliferation
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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