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Invitrogen
WAVE1 Polyclonal Antibody
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Product Details
PA5-82134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WASF1. Recombinant protein control fragment (Product #RP-102118).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PRAPHDRRRE WQKLAQGPEL AEDDANLLHK HIEVANGPAS HFETRPQTYV DHMDGSYSLS ALPFSQMSEL LTRAEERVLV RPHEPPPPPP MHGAGDAKPI PTCISSATGL IENRPQSPAT GRTPVFVSPT P
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 97%.
Target Information
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-binding protein WASF1; homology of dictyostelium scar 1; KIAA0269; Protein WAVE-1; Verprolin homology domain-containing protein 1; WAS protein family; WAS protein family member 1; WASP family protein member 1; WASP-family protein; WAVE; Wiskott-Aldrich syndrome protein family member 1
Gene Aliases: KIAA0269; NEDALVS; SCAR1; WASF1; WAVE; WAVE-1; WAVE1
UniProt ID: (Human) Q92558
Entrez Gene ID: (Human) 8936
receptor-mediated endocytosis
mitochondrion organization
Rac protein signal transduction
actin cytoskeleton organization
actin filament polymerization
neuron projection development
positive regulation of neurotrophin TRK receptor signaling pathway
protein-containing complex assembly
lamellipodium morphogenesis
dendrite extension
modification of postsynaptic actin cytoskeleton
dendritic transport of mitochondrion
cellular response to brain-derived neurotrophic factor stimulus
positive regulation of Arp2/3 complex-mediated actin nucleation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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