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Invitrogen
GIT1 Polyclonal Antibody
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Product Details
PA5-82143
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GIT1. Recombinant protein control fragment (Product #RP-102395).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DLDDQHDYDS VASDEDTDQE PLRSTGATRS NRARSMDSSD LSDGAVTLQE YLELKKALAT SEAKVQQLMK VSSSLSDELR RLQREIHKLQ AENLQLRQPP GPVPTPPLPS ERAEHTPMAP GGSTHRRDRQ AFSMYEPGSA L
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
GIT1 is a GTPase-activating protein for the ADP ribosylation factor family. It may serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. It increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; p95-APP1; unnamed protein product
Gene Aliases: GIT1; p95-APP1
UniProt ID: (Human) Q9Y2X7
Entrez Gene ID: (Human) 28964
GTPase activator activity
protein binding
zinc ion binding
protein phosphatase binding
small GTPase binding
identical protein binding
gamma-tubulin binding
macromolecular complex binding
metal ion binding
scaffold protein binding
structural constituent of postsynaptic specialization
protein tyrosine kinase binding
immunological synapse formation
intramembranous ossification
brain development
locomotory behavior
regulation of G-protein coupled receptor protein signaling pathway
regulation of ARF protein signal transduction
negative regulation of ARF protein signal transduction
regulation of cytokinesis
negative regulation of interleukin-1 beta production
synaptic vesicle recycling
cell redox homeostasis
negative regulation of glycolytic process
ephrin receptor signaling pathway
neuron development
dendritic spine development
motor learning
cellular response to lipopolysaccharide
cellular response to epidermal growth factor stimulus
positive regulation of microtubule nucleation
maintenance of postsynaptic specialization structure
presynaptic modulation of chemical synaptic transmission
neurotransmitter receptor localization to postsynaptic specialization membrane
negative regulation of inflammatory response to wounding
regulation of synaptic vesicle exocytosis
positive regulation of receptor catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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