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Invitrogen
CHP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82255
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHP1. Recombinant protein control fragment (Product #RP-89506).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GFSHSQITRL YSRFTSLDKG ENGTLSREDF QRIPELAINP LGDRIINAFF PEGEDQVNFR GFMRTLAHFR PIEDNEKSKD VNGPEPLNSR SNKLHFAFRL YDLDKDEKIS RDELLQVLRM MVGVNIS
Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcineurin B homolog; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22; CHP; EF-hand calcium-binding domain-containing protein p22; SLC9A1 binding protein; unnamed protein product
Gene Aliases: CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9
UniProt ID: (Human) Q99653
Entrez Gene ID: (Human) 11261
microtubule bundle formation
negative regulation of protein phosphorylation
negative regulation of protein kinase activity
protein export from nucleus
potassium ion transport
cellular sodium ion homeostasis
small GTPase mediated signal transduction
positive regulation of glycoprotein biosynthetic process
negative regulation of phosphatase activity
membrane docking
cytoplasmic microtubule organization
negative regulation of protein ubiquitination
negative regulation of protein autophosphorylation
positive regulation of sodium:proton antiporter activity
sodium ion transmembrane transport
regulation of protein import into nucleus
negative regulation of protein import into nucleus
protein stabilization
positive regulation of protein transport
regulation of intracellular pH
membrane organization
membrane fusion
regulation of calcineurin-NFAT signaling cascade
negative regulation of calcineurin-NFAT signaling cascade
positive regulation of phospholipid biosynthetic process
cellular response to acidic pH
positive regulation of protein targeting to membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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