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Invitrogen
FEN1 Polyclonal Antibody
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Product Details
PA5-82261
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FEN1. Recombinant protein control fragment (Product #RP-89493).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CAALVKAGKV YAAATEDMDC LTFGSPVLMR HLTASEAKKL PIQEFHLSRI LQELGLNQEQ FVDLCILLGS DYCESIRGIG PKRAVDLIQK HKSIEEIVRR LDPNKYPVPE NWLHKEAHQL FLEPEVLDPE SVELKW
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 97%.
Target Information
FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 a protein that functions as an endonuclease that cleaves branched DNA structures containing single-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNase IV; FEN-1; FEN-1 {ECO:0000255|HAMAP-Rule:MF_03140}; FEN1; fen1 {ECO:0000255|HAMAP-Rule:MF_03140}; Flap endonuclease 1; flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}; Flap structure-specific endonuclease 1; flap structure-specific endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}; hFEN-1; Maturation factor 1; maturation factor-1; MF1; unnamed protein product
Gene Aliases: AW538437; FEN-1; FEN1; MF1; RAD2
UniProt ID: (Human) P39748, (Rat) Q5XIP6
Entrez Gene ID: (Human) 2237, (Mouse) 14156, (Rat) 84490
magnesium ion binding
DNA binding
damaged DNA binding
double-stranded DNA binding
catalytic activity
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
RNA-DNA hybrid ribonuclease activity
exonuclease activity
protein binding
double-stranded DNA exodeoxyribonuclease activity
5'-3' exonuclease activity
hydrolase activity
hydrolase activity, acting on ester bonds
5'-flap endonuclease activity
manganese ion binding
metal ion binding
flap endonuclease activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
exodeoxyribonuclease
double-strand break repair via homologous recombination
DNA replication
DNA repair
base-excision repair
base-excision repair, gap-filling
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
memory
UV protection
telomere maintenance via semi-conservative replication
DNA replication, removal of RNA primer
positive regulation of sister chromatid cohesion
DNA metabolic process
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, endonucleolytic
DNA catabolic process, endonucleolytic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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