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Invitrogen
MLK2 Polyclonal Antibody
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Product Details
PA5-82276
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MAP3K10. Recombinant protein control fragment (Product #RP-89758).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LPSGFEHKIT VQASPTLDKR KGSDGASPPA SPSIIPRLRA IRLTPVDCGG SSSGSSSGGS GTWSRGGPPK KEELVGGKKK GRTWGPSSTL QKERVGGEER LKGLGEGSKQ WSSS
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 92%.
Target Information
MAP3K10 (MLK2) is a serine/threonine kinase which has been shown to activate MAPK8/JNK and MKK4/SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; PRKE1; Protein kinase MST
Gene Aliases: MAP3K10; MEKK10; MLK2; MST
UniProt ID: (Human) Q02779
Entrez Gene ID: (Human) 4294
nucleotide binding
transcription corepressor activity
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein homodimerization activity
bHLH transcription factor binding
protein serine kinase activity
apoptotic process
signal transduction
smoothened signaling pathway
JNK cascade
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
protein autophosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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