Search
Invitrogen
Glutamine Synthetase Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 7
Glutamine Synthetase Antibody (PA5-82295) in IHC (P)
Immunohistochemistry analysis of Glutamine Synthetase in human cerebellum, cerebral cortex, kidney and liver. Samples were incubated with Glutamine Synthetase polyclonal antibody (Product # PA5-82295). Shows similar protein distribution across tissues to independent Glutamine Synthetase antibody (Product # PA5-82305) (B).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82295
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GLUL. Recombinant protein control fragment (Product #RP-88685).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LQSEGSNSDM YLVPAAMFRD PFRKDPNKLV LCEVFKYNRR PAETNLRHTC KRIMDMVSNQ HPWFGMEQEY TLMGTDGHPF GWPSNGFPGP QGPYYCGVGA DRAYGRDIVE AHYRACLYAG VKIAGTNAEV MPAQWEFQIG P
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 95%.
Target Information
Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: cell proliferation-inducing protein 59; GLNA; Glutamate ammonia ligase; glutamate decarboxylase; glutamine synthase; glutamine synthetase I; palmitoyltransferase GLUL; Proliferation inducing protein 43; proliferation-inducing protein 43; unnamed protein product
Gene Aliases: DEE116; GLNS; GS; PIG43; PIG59
UniProt ID: (Human) P15104
Entrez Gene ID: (Human) 2752
glutamate catabolic process
cell proliferation
regulation of endothelial cell migration
protein palmitoylation
ribosome biogenesis
positive regulation of erythrocyte differentiation
cellular ammonia homeostasis
L-glutamine biosynthetic process
regulation of sprouting angiogenesis
regulation of protein localization to nucleolus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support