Search
Invitrogen
Podoplanin Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-82301
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDPN. Recombinant protein control fragment (Product #RP-96786).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RLPRVWEARA PSLSGAPAPT PPAPPPSRSS RLGLWPRCFL IFPQLRILLL GPQESNNSTG TMWKVSALLF VLGSASLWVL AEGASTGQPE DDTETTGLEG GVAMPGAEDD VVTPGTSEDR YKSGLTTLVA TSVNS
Highest antigen sequence indentity to the following orthologs: Mouse - 25%, Rat - 25%.
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aggrus; CTA-520D8.1; Glycoprotein 36; glycoprotein, 36-KD; Gp36; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); lung type-I cell membrane-associated protein; membrane associated mucin-type glycoprotein; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26 antigen; Podoplanin; RP23-348F1.2; T1-alpha; T1A; transmembrane mucin-type glycoprotein; unnamed protein product
Gene Aliases: AGGRUS; D2-40; GP36; Gp38; GP40; HT1A-1; OTS8; PA2.26; PDPN; PSEC0003; PSEC0025; T1A; T1A-2; T1A2; TI1A
UniProt ID: (Human) Q86YL7
Entrez Gene ID: (Human) 10630
lymphangiogenesis
water transport
amino acid transport
cell adhesion
signal transduction
Rho protein signal transduction
negative regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
folic acid transport
cell migration
platelet activation
lung development
positive regulation of cell migration
negative regulation of apoptotic process
wound healing, spreading of cells
lymph node development
lymphatic endothelial cell fate commitment
actin-mediated cell contraction
positive regulation of extracellular matrix disassembly
regulation of substrate adhesion-dependent cell spreading
positive regulation of platelet aggregation
regulation of myofibroblast contraction
regulation of lamellipodium morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support