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Invitrogen
JMJD2A Polyclonal Antibody
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Product Details
PA5-82307
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KDM4A. Recombinant protein control fragment (Product #RP-89680).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DVFVRKFQPE RYKLWKAGKD NTVIDHTLPT PEAAEFLKES ELPPRAGNEE ECPEEDMEGV EDGEEGDLKT SLAKHRIGTK RHRVCLEIPQ EVSQSELFPK EDLSSEQYEM TEC
Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 88%.
Target Information
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A; tudor domain containing 14A; unnamed protein product
Gene Aliases: JHDM3A; JMJD2; JMJD2A; KDM4A; KIAA0677; TDRD14A
UniProt ID: (Human) O75164
Entrez Gene ID: (Human) 9682
protein binding
zinc ion binding
oxidoreductase activity
ubiquitin protein ligase binding
histone demethylase activity
histone demethylase activity (H3-K9 specific)
metal ion binding
dioxygenase activity
histone demethylase activity (H3-K36 specific)
histone H4K20me2 reader activity
histone H3K36me2/H3K36me3 demethylase activity
histone H3K9me2/H3K9me3 demethylase activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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