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Invitrogen
TGFBR3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82343
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TGFBR3. Recombinant protein control fragment (Product #RP-88952).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GYSGMDVTLL DPTCKAKMNG THFVLESPLN GCGTRPRWSA LDGVVYYNSI VIQVPALGDS SGWPDGYEDL ESGDNGFPGD MDEGDASLFT RPEIVVFNCS LQQVRNPSSF QEQPHGNITF NMELYNTDLF
Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 78%.
Target Information
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: betaglycan proteoglycan; OTTHUMP00000011787; tgf beta receptor 3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; transforming growth factor beta receptor III; unnamed protein product
Gene Aliases: betaglycan; BGCAN
UniProt ID: (Human) Q03167
Entrez Gene ID: (Human) 7049
transmembrane signaling receptor activity
transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
protein binding
glycosaminoglycan binding
heparin binding
coreceptor activity
fibroblast growth factor binding
PDZ domain binding
BMP binding
SMAD binding
activin binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type III
response to hypoxia
epithelial to mesenchymal transition
liver development
heart morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
ventricular compact myocardium morphogenesis
immune response
transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor complex assembly
positive regulation of gene expression
cell migration
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cell migration
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
response to follicle-stimulating hormone
response to prostaglandin E
response to luteinizing hormone
intracellular signal transduction
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of JNK cascade
animal organ development
negative regulation of epithelial cell proliferation
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
definitive hemopoiesis
cardiac epithelial to mesenchymal transition
definitive erythrocyte differentiation
heart trabecula formation
positive regulation of SMAD protein import into nucleus
negative regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
epicardium-derived cardiac fibroblast cell development
vasculogenesis involved in coronary vascular morphogenesis
heart trabecula morphogenesis
secondary palate development
protein-containing complex assembly
regulation of ERK1 and ERK2 cascade
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of extracellular matrix assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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