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Invitrogen
TGFBR3 Polyclonal Antibody
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Product Details
PA5-82343
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TGFBR3. Recombinant protein control fragment (Product #RP-88952).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: GYSGMDVTLL DPTCKAKMNG THFVLESPLN GCGTRPRWSA LDGVVYYNSI VIQVPALGDS SGWPDGYEDL ESGDNGFPGD MDEGDASLFT RPEIVVFNCS LQQVRNPSSF QEQPHGNITF NMELYNTDLF
Highest antigen sequence indentity to the following orthologs: Rat - 78%, Mouse - 78%.
Target Information
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Betaglycan; betaglycan proteoglycan; OTTHUMP00000011787; tgf beta receptor 3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3
Gene Aliases: betaglycan; BGCAN; TGFBR3
UniProt ID: (Human) Q03167
Entrez Gene ID: (Human) 7049
transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
protein binding
glycosaminoglycan binding
heparin binding
coreceptor activity
fibroblast growth factor binding
PDZ domain binding
SMAD binding
activin binding
transforming growth factor beta binding
transforming growth factor beta receptor activity, type III
transmembrane signal receptor
response to hypoxia
epithelial to mesenchymal transition
liver development
heart morphogenesis
immune response
transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor complex assembly
cell growth
cell migration
BMP signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
organ regeneration
response to follicle-stimulating hormone
response to prostaglandin E
response to luteinizing hormone
intracellular signal transduction
regulation of protein binding
negative regulation of epithelial cell proliferation
negative regulation of cellular component movement
ventricular cardiac muscle tissue morphogenesis
palate development
cardiac muscle cell proliferation
definitive hemopoiesis
cardiac epithelial to mesenchymal transition
definitive erythrocyte differentiation
heart trabecula formation
pathway-restricted SMAD protein phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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