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Invitrogen
RhoGAP Polyclonal Antibody
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Product Details
PA5-82344
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ARHGAP1. Recombinant protein control fragment (Product #RP-102446).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DFDQYNELHL PAVILKTFLR ELPEPLLTFD LYPHVVGFLN IDESQRVPAT LQVLQTLPEE NYQVLRFLTA FLVQISAHSD QNKMTNTNLA VVFGPNLLWA KDAAITLKAI NPINTFTKFL LDHQGELF
Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 96%.
Target Information
The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells. It functions as a GTPase - activating protein (GAP) for Rho and Rac family proteins, which are involved in regulating cytoskeletal actin and membrane ruffling. The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP. The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42 GTPase-activating protein; GFI2; GTPase-activating protein rhoGAP; GTPase-activating protein rhoOGAP; GTPase-activating protein, Rho, 1; p105 RhoGAP; p190-B; p190BRhoGAP; p50-RhoGAP; Rho GTPase-activating protein 1; Rho-related small GTPase protein activator; Rho-type GTPase-activating protein 1; RhoGAP5; unnamed protein product
Gene Aliases: ARHGAP1; B230365D05Rik; C76222; CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1
UniProt ID: (Human) Q07960, (Mouse) Q5FWK3
Entrez Gene ID: (Human) 392, (Rat) 311193, (Mouse) 228359
signal transduction
small GTPase mediated signal transduction
Rho protein signal transduction
endosomal transport
transferrin transport
regulation of small GTPase mediated signal transduction
negative regulation of endocytic recycling
regulation of GTPase activity
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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