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Invitrogen
DAXX Polyclonal Antibody
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Product Details
PA5-82362
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DAXX. Recombinant protein control fragment (Product #RP-102461).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV LENGAGMVSS TSFNGGVSPH NWGDSG
Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 50%.
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CENP-C binding protein; DADB-159G18.9; DAXX; Death domain-associated protein 6; death domain-binding protein; HDaxx; death-associated protein 6; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126245; MGC126246; SMIM40; unnamed protein product
Gene Aliases: BING2; DAP6; DAXX; EAP1; SMIM40
UniProt ID: (Human) Q9UER7
Entrez Gene ID: (Human) 1616
p53 binding
transcription coactivator activity
transcription corepressor activity
protein binding
enzyme binding
protein kinase binding
protein kinase activator activity
heat shock protein binding
ubiquitin protein ligase binding
histone binding
protein homodimerization activity
androgen receptor binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
molecular condensate scaffold activity
chromatin organization
nucleosome assembly
chromatin remodeling
regulation of transcription, DNA-templated
apoptotic process
JNK cascade
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
negative regulation of gene expression
androgen receptor signaling pathway
regulation of protein ubiquitination
cellular response to heat
cellular response to unfolded protein
neuron intrinsic apoptotic signaling pathway in response to oxidative stress
regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cellular response to cadmium ion
cellular response to copper ion
cellular response to diamide
cellular response to sodium arsenite
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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