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Invitrogen
Desmocollin 2 Polyclonal Antibody
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FIGURE: 1 / 7
Desmocollin 2 Antibody (PA5-82441) in IHC (P)
Immunohistochemistry analysis of Desmocollin 2 in human colon, esophagus, liver and tonsil. Samples were incubated with Desmocollin 2 polyclonal antibody (Product # PA5-82441). Shows similar protein distribution across tissues to independent Desmocollin 2 antibody (Product # PA5-82465) (B).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82441
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DSC2. Recombinant protein control fragment (Product #RP-90653).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IGVVNEAPFS REASPRSAMS TATVTVNVED QDEGPECNPP IQTVRMKENA EVGTTSNGYK AYDPETRSSS GIRYKKLTDP TGWVTIDENT GSIKVFRSLD REAETIKNGI YNITVLASDQ GGRTCTGTLG IILQDVNDNS
Highest antigen sequence indentity to the following orthologs: Rat - 70%, Mouse - 75%.
Target Information
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARVC10; ARVD10; Cadherin family member 2; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III; HDGC; PVA
Gene Aliases: CDHF2; DSC2; DSC3
Entrez Gene ID: (Human) 1824
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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