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Invitrogen

ErbB4 Polyclonal Antibody

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ErbB4 Polyclonal Antibody

Product Details

PA5-82452

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ERBB4. Recombinant protein control fragment (Product #RP-88798).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789610

Product Specific Information

Immunogen sequence: LPSPNDSKFF QNLLDEEDLE DMMDAEEYLV PQAFNIPPPI YTSRARIDSN RNQFVYRDGG FAAEQGVSVP YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRK

Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 79%.

Target Information

Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; human epidermal growth factor receptor 4; OTTHUMP00000209432; p180erbB4; Proto-oncogene-like protein c-ErbB-4; Receptor tyrosine-protein kinase erbB-4; Tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

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Gene Aliases: ALS19; ERBB4; HER4; p180erbB4

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UniProt ID: (Human) Q15303

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Entrez Gene ID: (Human) 2066

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Function(s)
nucleotide binding transcription regulatory region sequence-specific DNA binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity epidermal growth factor-activated receptor activity epidermal growth factor receptor binding protein binding ATP binding kinase activity transferase activity neuregulin receptor activity protein homodimerization activity GABA receptor binding
Process(es)
neural crest cell migration positive regulation of protein phosphorylation apoptotic process signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway JAK-STAT cascade nervous system development synapse assembly heart development lactation positive regulation of cell proliferation negative regulation of cell proliferation embryonic pattern specification positive regulation of biosynthetic process cell migration peptidyl-tyrosine phosphorylation central nervous system morphogenesis olfactory bulb interneuron differentiation neuron differentiation regulation of cell migration mammary gland development ERBB4 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway positive regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process positive regulation of MAPK cascade mitochondrial fragmentation involved in apoptotic process cell fate commitment positive regulation of transcription, DNA-templated positive regulation of phosphate metabolic process positive regulation of JAK-STAT cascade protein autophosphorylation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling positive regulation of cardiac muscle cell proliferation mammary gland epithelial cell differentiation mammary gland alveolus development cardiac muscle tissue regeneration regulation of biological quality positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus establishment of planar polarity involved in nephron morphogenesis neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of protein localization to cell surface negative regulation of neuron migration
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