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Invitrogen
PLD2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82482
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PLD2. Recombinant protein control fragment (Product #RP-90753).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CFGVILGANT RPDLDLRDPI CDDFFQLWQD MAESNANIYE QIFRCLPSNA TRSLRTLREY VAVEPLATVS PPLARSELTQ VQGHLVHFPL KFLEDESLLP
Highest antigen sequence indentity to the following orthologs: Rat - 85%, Mouse - 86%.
Target Information
PLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; splice variant hPLD2a; splice variant hPLD2b; unnamed protein product
Gene Aliases: PLD1C
UniProt ID: (Human) O14939
Entrez Gene ID: (Human) 5338
phosphatidic acid biosynthetic process
cytoskeleton organization
small GTPase mediated signal transduction
phospholipid catabolic process
intracellular signal transduction
synaptic vesicle recycling
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of vesicle-mediated transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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