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Invitrogen
Calponin 1 Polyclonal Antibody
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Product Details
PA5-82499
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CNN1. Recombinant protein control fragment (Product #RP-89632).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PLDQATISLQ MGTNKGASQA GMTAPGTKRQ IFEPGLGMEH CDTLNVSLQM GSNKGASQRG MTVYGLPRQV YDPKYCLTPE YPELGEPAHN HHAHNYYNS
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 97%.
Target Information
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Basic calponin; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; Calponin H1, smooth muscle; Calponin-1; calponins, basic; epididymis secretory protein Li 14
Gene Aliases: CN; CNN1; CnnI; HEL-S-14; Sm-Calp; SMCC
UniProt ID: (Human) P51911, (Mouse) Q08091, (Rat) Q08290
Entrez Gene ID: (Human) 1264, (Mouse) 12797, (Rat) 65204
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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