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Invitrogen
PTPN2 Polyclonal Antibody
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Product Details
PA5-82516
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTPN2. Recombinant protein control fragment (Product #RP-90507).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DDINIKQVLL NMRKYRMGLI QTPDQLRFSY MAIIEGAKCI KGDSSIQKRW KELSKEDLSP AFDHSPNKIM TEKYNGNRIG LEEEKLTGDR CTGLSSKMQD TMEENSESAL RKRIREDRKA TTAQKVQQMK QRLNENERK
Highest antigen sequence indentity to the following orthologs: Mouse - 81%, Rat - 68%.
Target Information
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PTPN 2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC PTP; TCPTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2; unnamed protein product
Gene Aliases: PTN2; PTPN2; PTPT; TC-PTP; TC45; TC48; TCELLPTP; TCPTP
UniProt ID: (Human) P17706
Entrez Gene ID: (Human) 5771
negative regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
B cell differentiation
T cell differentiation
erythrocyte differentiation
peptidyl-tyrosine dephosphorylation
insulin receptor recycling
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tyrosine phosphorylation of STAT protein
glucose homeostasis
negative regulation of macrophage differentiation
positive regulation of gluconeogenesis
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of T cell receptor signaling pathway
negative regulation of chemotaxis
regulation of interferon-gamma-mediated signaling pathway
negative regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
negative regulation of positive thymic T cell selection
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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