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Invitrogen
HLTF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82525
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HLTF. Recombinant protein control fragment (Product #RP-91601).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKKHGFKLGP APKTLGFNLE SGWGSGRAGP SYSMPVHAAV QMTTEQLKTE FDKLFEDLKE DDKTHEMEPA EAIETPLLPH QKQALAWMVS RENSKELPPF WEQRNDLYYN TITNFSEKDR PENVHGGILA DDMGLGK
Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 89%.
Target Information
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA binding and RING finger protein; DNA-binding protein/plasminogen activator inhibitor-1 regulator; helicase-like transcription factor; mem; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SNF2-like 3; sucrose nonfermenting protein 2-like 3; sucrose nonfermenting-like 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; TNF-response element-binding protein; unnamed protein product
Gene Aliases: HIP116; HIP116A; HLTF1; P113; RNF80; SMARCA3; SNF2L3; ZBU1
UniProt ID: (Human) Q14527, (Mouse) Q6PCN7
Entrez Gene ID: (Human) 6596, (Rat) 295568, (Mouse) 20585
nucleic acid binding
single-stranded DNA binding
RNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
zinc ion binding
DNA translocase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
ubiquitin protein ligase binding
ubiquitin protein ligase activity
histone H3K9me2/3 reader activity
histone H3K23 ubiquitin ligase activity
ATP-dependent chromatin remodeler activity
G-quadruplex unwinding activity
protein polyubiquitination
DNA repair
chromatin remodeling
cellular response to DNA damage stimulus
protein ubiquitination
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
protein K63-linked ubiquitination
protein localization to chromatin
replication fork reversal
chromosomal DNA methylation maintenance following DNA replication
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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