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Invitrogen
HLTF Polyclonal Antibody
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Product Details
PA5-82525
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HLTF. Recombinant protein control fragment (Product #RP-91601).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKKHGFKLGP APKTLGFNLE SGWGSGRAGP SYSMPVHAAV QMTTEQLKTE FDKLFEDLKE DDKTHEMEPA EAIETPLLPH QKQALAWMVS RENSKELPPF WEQRNDLYYN TITNFSEKDR PENVHGGILA DDMGLGK
Highest antigen sequence indentity to the following orthologs: Rat - 88%, Mouse - 89%.
Target Information
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein/plasminogen activator inhibitor 1 regulator; DNA-binding protein/plasminogen activator inhibitor-1 regulator; DNA-dependent ATPase/E3 ubiquitin-protein ligase HLTF; Helicase-like transcription factor; HIP116; HLTF; mem; P113; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SMARCA3; SNF2-like 3; Sucrose nonfermenting protein 2-like 3; sucrose nonfermenting-like 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; TNF-response element-binding protein; unnamed protein product
Gene Aliases: AF010600; BC057116; HIP116; HIP116A; HLTF; HLTF1; P113; RNF80; SMARCA3; SNF2L3; ZBU1
UniProt ID: (Human) Q14527, (Mouse) Q6PCN7
Entrez Gene ID: (Human) 6596, (Mouse) 20585, (Rat) 295568
nucleotide binding
nucleic acid binding
DNA binding
single-stranded DNA binding
RNA binding
catalytic activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
zinc ion binding
DNA translocase activity
transferase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ubiquitin protein ligase binding
metal ion binding
ubiquitin protein ligase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ATPase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
poly(A) RNA binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protein polyubiquitination
DNA repair
chromatin organization
cellular response to DNA damage stimulus
protein ubiquitination
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
replication fork reversal
postreplication repair
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
metabolic process
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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