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Invitrogen
Fibrillin 1 Polyclonal Antibody
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Product Details
PA5-82598
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FBN1. Recombinant protein control fragment (Product #RP-90823).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HCVSGMGMGR GNPEPPVSGE MDDNSLSPEA CYECKINGYP KRGRKRRSTN ETDASNIEDQ SETEANVSLA SWDVEKTAIF AFNISHVSNK VRILELLPAL TTLTNHNRYL IESGNEDGFF KINQKEGISY LHFTKKKPVA GTYSLQISS
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 91%.
Target Information
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: asprosin; epididymis secretory sperm binding protein; fibrillin 15; Fibrillin-1; fibrillin-1 preproprotein; unnamed protein product
Gene Aliases: ACMICD; ECTOL1; FBN; FBN1; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; WMS; WMS2
UniProt ID: (Human) P35555
Entrez Gene ID: (Human) 2200
skeletal system development
metanephros development
kidney development
glucose metabolic process
signal transduction
heart development
gene expression
protein kinase A signaling
lung development
positive regulation of appetite
cell adhesion mediated by integrin
activation of protein kinase A activity
sequestering of BMP in extracellular matrix
sequestering of TGFbeta in extracellular matrix
glucose homeostasis
camera-type eye development
negative regulation of osteoclast differentiation
embryonic eye morphogenesis
post-embryonic eye morphogenesis
lung alveolus development
cellular response to transforming growth factor beta stimulus
cellular response to insulin-like growth factor stimulus
negative regulation of osteoclast development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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