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Invitrogen
Cathepsin B Polyclonal Antibody
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Product Details
PA5-82618
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CTSB. Recombinant protein control fragment (Product #RP-91308).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DELVNYVNKR NTTWQAGHNF YNVDMSYLKR LCGTFLGGPK PPQRVMFTED LKLPASFDAR EQWPQCPTIK EIRDQGSCGS CWAFGAVEAI SDRICIHTNA HVSVEVSAED LLTCCGSMCG DGCNGGYPA
Highest antigen sequence indentity to the following orthologs: Rat - 79%, Mouse - 79%.
Target Information
Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; Cathepsin B1; cysteine protease; epididymis secretory sperm binding protein; keratolytic winter erythema (Oudtshoorn skin disease); lysosomal proteinase cathepsin B; preprocathepsin B; unnamed protein product
Gene Aliases: APPS; CPSB; CTSB; KWE; RECEUP
UniProt ID: (Human) P07858
Entrez Gene ID: (Human) 1508
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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