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Invitrogen
TOP1 Polyclonal Antibody
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Product Details
PA5-82658
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TOP1. Recombinant protein control fragment (Product #RP-92579).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KVRASGDAKI KKEKENGFSS PPQIKDEPED DGYFVPPKED IKPLKRPRDE DDADYKPKK
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 92%.
Target Information
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA topoisomerase 1; DNA topoisomerase I; RP3-511B24.2; Topoisomerase 1; type I DNA topoisomerase
Gene Aliases: Ab2-086; AI467334; D130064I21Rik; Top-1; TOP1; TOPI
UniProt ID: (Human) P11387, (Rat) Q9WUL0, (Mouse) Q04750
Entrez Gene ID: (Human) 7150, (Rat) 64550, (Mouse) 21969
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
DNA topoisomerase type I activity
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein binding
poly(A) RNA binding
chromatin DNA binding
protein complex binding
DNA topoisomerase activity
isomerase activity
DNA topoisomerase
DNA replication
DNA topological change
chromatin remodeling
chromosome segregation
circadian rhythm
programmed cell death
viral process
phosphorylation
protein sumoylation
circadian regulation of gene expression
embryonic cleavage
response to drug
response to temperature stimulus
rRNA transcription
response to gamma radiation
organ regeneration
response to cAMP
cellular response to luteinizing hormone stimulus
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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