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Invitrogen
DUSP8 Polyclonal Antibody
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Product Details
PA5-82712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DUSP8. Recombinant protein control fragment (Product #RP-91582).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SDDAYRFVKD RRPSISPNFN FLGQLLEYER SLKLLAALQG DPGTPSGTPE PPPSPAAGAP LPRLPPPTSE SAATGNAAAR
Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 84%.
Target Information
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH-5; FLJ42476; FLJ42958; H1 phosphatase, vaccinia virus homolog; OTTHUMP00000164487; serine/threonine specific protein phosphatase; unnamed protein product
Gene Aliases: C11orf81; DUSP8; HB5; HVH-5; HVH8; VH5
UniProt ID: (Human) Q13202
Entrez Gene ID: (Human) 1850
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/threonine phosphatase activity
hydrolase activity
phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
MAP kinase tyrosine phosphatase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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