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Invitrogen
Ezrin Polyclonal Antibody
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Product Details
PA5-82769
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EZR. Recombinant protein control fragment (Product #RP-101067).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: REEKHQKQLE RQQLETEKKR RETVEREKEQ MMREKEELML RLQDYEEKTK KAERELSEQI QRALQLEEER KRAQEEAERL EADRMAALRA KEELERQAVD QIKSQEQLAA ELAEYTAKIA LLE
Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; unnamed protein product; villin 2; villin 2 (ezrin); villin 2; CVL; villin 2; kinase substrate; Villin-2
Gene Aliases: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2
UniProt ID: (Human) P15311, (Mouse) P26040, (Rat) P31977
Entrez Gene ID: (Human) 7430, (Mouse) 22350, (Rat) 54319
RNA binding
actin binding
protein binding
microtubule binding
cytoskeletal protein binding
protein domain specific binding
protein kinase A catalytic subunit binding
protein kinase A regulatory subunit binding
identical protein binding
S100 protein binding
cadherin binding
cell adhesion molecule binding
actin filament binding
protein kinase A binding
ATPase binding
disordered domain specific binding
protein complex binding
poly(A) RNA binding
structural molecule activity
actin or actin-binding cytoskeletal protein
negative regulation of transcription from RNA polymerase II promoter
intestinal D-glucose absorption
sphingosine-1-phosphate signaling pathway
leukocyte cell-cell adhesion
regulation of cell shape
positive regulation of gene expression
protein kinase A signaling
gland morphogenesis
membrane to membrane docking
microvillus assembly
actin cytoskeleton organization
astral microtubule organization
protein complex localization
receptor internalization
regulation of microvillus length
negative regulation of interleukin-2 production
regulation of actin cytoskeleton organization
establishment or maintenance of apical/basal cell polarity
positive regulation of multicellular organism growth
cortical microtubule organization
establishment of epithelial cell apical/basal polarity
positive regulation of protein catabolic process
filopodium assembly
negative regulation of T cell receptor signaling pathway
actin filament bundle assembly
establishment of centrosome localization
establishment of endothelial barrier
negative regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to plasma membrane
protein localization to cell cortex
postsynaptic actin cytoskeleton organization
regulation of NIK/NF-kappaB signaling
regulation of organelle assembly
terminal web assembly
positive regulation of protein localization to early endosome
positive regulation of protein localization to plasma membrane
negative regulation of p38MAPK cascade
positive regulation of early endosome to late endosome transport
actin cytoskeleton reorganization
phosphatidylinositol-mediated signaling
positive regulation of protein secretion
positive regulation of establishment of protein localization to plasma membrane
positive regulation of cellular protein catabolic process
epithelial cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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