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Invitrogen

RACK1 Polyclonal Antibody

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RACK1 Polyclonal Antibody

Product Details

PA5-82771

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RACK1. Recombinant protein control fragment (Product #RP-92500).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789927

Product Specific Information

Immunogen sequence: CVRFSPNSSN PIIVSCGWDK LVKVWNLANC KLKTNHIGHT GYLNTVTVSP DGSLCASGGK DGQAMLWDLN EGKHLYTLDG

Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

Target Information

RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta-2, related sequence 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; p205; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; rack-1; Receptor for activated C kinase; Receptor for activated C kinase 1; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1; unnamed protein product

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Gene Aliases: AL033335; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; p205; PIG21; RACK1

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UniProt ID: (Mouse) P68040, (Human) P63244

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Entrez Gene ID: (Mouse) 14694, (Human) 10399

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Function(s)
receptor activity protein kinase C binding protein binding ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein phosphatase binding protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding signaling adaptor activity SH2 domain binding protein homodimerization activity poly(A) RNA binding RNA binding receptor binding enzyme activator activity protein serine/threonine kinase inhibitor activity cyclin binding identical protein binding ribosome binding translation regulator activity cadherin binding BH3 domain binding binding, bridging
Process(es)
osteoblast differentiation positive regulation of protein phosphorylation regulation of translation apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell cycle multicellular organism development gastrulation protein localization negative regulation of gene expression negative regulation of translation negative regulation of cell growth positive regulation of cell migration positive regulation of cAMP catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein homooligomerization negative regulation of peptidyl-serine phosphorylation intracellular signal transduction regulation of growth positive regulation of apoptotic process positive regulation of GTPase activity rhythmic process negative regulation of phagocytosis positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization negative regulation of protein tyrosine kinase activity cellular response to glucose stimulus regulation of establishment of protein localization to plasma membrane negative regulation of hydrogen peroxide-induced neuron death positive regulation of intrinsic apoptotic signaling pathway cytoplasmic translation translation protein ubiquitination negative regulation of Wnt signaling pathway positive regulation of protein complex assembly negative regulation of protein binding regulation of protein localization positive regulation of Golgi to plasma membrane protein transport pigmentation negative regulation of smoothened signaling pathway regulation of cell division cellular response to growth factor stimulus rescue of stalled ribosome regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of endoplasmic reticulum unfolded protein response negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide regulation of establishment of cell polarity positive regulation of gastrulation negative regulation of translational frameshifting
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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