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Invitrogen

Fyn Polyclonal Antibody

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Fyn Polyclonal Antibody

Product Details

PA5-82851

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FYN. Recombinant protein control fragment (Product #RP-95941).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790007

Product Specific Information

Immunogen sequence: SFGVTSIPNY NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR

Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

Target Information

FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; fyn {ECO:0000312|RGD:2641}; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; src-like tyrosine kinase (put.); putative; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn; unnamed protein product

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Gene Aliases: AI448320; AW552119; FYN; p59-FYN; SLK; SYN

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UniProt ID: (Human) B5BU57, (Rat) Q62844, (Mouse) P39688

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Entrez Gene ID: (Human) 2534, (Rat) 25150, (Mouse) 14360

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Function(s)
nucleotide binding G-protein coupled receptor binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding tubulin binding phospholipase activator activity kinase activity transferase activity enzyme binding type 5 metabotropic glutamate receptor binding T cell receptor binding CD4 receptor binding CD8 receptor binding identical protein binding alpha-tubulin binding phospholipase binding phosphatidylinositol 3-kinase binding ion channel binding macromolecular complex binding metal ion binding ephrin receptor binding tau protein binding tau-protein kinase activity peptide hormone receptor binding growth factor receptor binding scaffold protein binding disordered domain specific binding glycoprotein binding protein complex binding transferase activity, transferring phosphorus-containing groups
Process(es)
response to singlet oxygen neuron migration stimulatory C-type lectin receptor signaling pathway adaptive immune response immune system process negative regulation of inflammatory response to antigenic stimulus heart process calcium ion transport cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled glutamate receptor signaling pathway axon guidance learning feeding behavior regulation of cell shape response to xenobiotic stimulus gene expression negative regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process positive regulation of neuron projection development negative regulation of angiogenesis protein ubiquitination peptidyl-tyrosine phosphorylation layer formation in cerebral cortex natural killer cell activation cell differentiation protein catabolic process forebrain development neuron projection development T cell costimulation negative regulation of protein ubiquitination intracellular signal transduction cellular response to platelet-derived growth factor stimulus reelin-mediated signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of protein catabolic process response to cocaine proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of neuron apoptotic process response to ethanol vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway dendrite morphogenesis activated T cell proliferation modulation of synaptic transmission T cell receptor signaling pathway leukocyte migration detection of mechanical stimulus involved in sensory perception of pain positive regulation of protein kinase B signaling cellular response to hydrogen peroxide cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus positive regulation of protein targeting to membrane dendritic spine maintenance positive regulation of protein localization to nucleus regulation of glutamate receptor signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of dendritic spine maintenance response to amyloid-beta cellular response to beta-amyloid cellular response to L-glutamate cellular response to glycine positive regulation of protein localization to membrane regulation of calcium ion import across plasma membrane regulation of neuron migration negative regulation of extrinsic apoptotic signaling pathway in absence of ligand protein phosphorylation central nervous system development positive regulation of phosphatidylinositol 3-kinase signaling cell migration ionotropic glutamate receptor signaling pathway peptidyl-tyrosine autophosphorylation T cell activation regulation of cell proliferation response to drug positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response protein autophosphorylation multicellular organism development phosphorylation myelination regulation of apoptotic process
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