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Invitrogen
DEPDC6 Polyclonal Antibody
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Product Details
PA5-82856
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DEPTOR. Recombinant protein control fragment (Product #RP-93836).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVTGEQLRLR LHEEKVIKDR RHHLKTYPNC FVAKELIDWL IEHKEASDRE TAIKLMQKLA DRGIIHHVCD EH
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
DEPDC6 is a gene that encodes a protein known for its role in various cellular processes, although the specifics of its function remain not fully elucidated. Located on chromosome 22, DEPDC6 is involved in regulating cell growth and survival by modulating the RAS signaling pathway, a crucial pathway for many cellular functions. Structurally, DEPDC6 contains a DEP domain, which is known to mediate interactions with other proteins that are involved in signal transduction. This domain plays a significant role in facilitating the proper localization and function of the protein. Functionally, DEPDC6 is implicated in controlling the pathways that govern the timing and progression of the cell cycle, highlighting its importance in maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Its dysregulation has been associated with various cancers, emphasizing the need for further studies to fully understand its potential as a therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DEP domain containing 6; DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6; hDEPTOR; unnamed protein product
Gene Aliases: DEP.6; DEPDC6; DEPTOR; hDEPTOR
UniProt ID: (Human) Q8TB45
Entrez Gene ID: (Human) 64798
autophagosome assembly
negative regulation of protein kinase activity
G-protein coupled receptor signaling pathway
negative regulation of autophagy
positive regulation of autophagy
cellular response to nutrient levels
negative regulation of TOR signaling
intracellular signal transduction
TORC1 signaling
negative regulation of cell size
negative regulation of TORC2 signaling
negative regulation of TORC1 signaling
regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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