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          • Primary Antibodies ›
          • PYK2 Antibodies

          Invitrogen

          PYK2 Polyclonal Antibody

          Advanced Verification
          View all (41) PYK2 antibodies

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          Cite PYK2 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (3)
          • Advanced Verification (1)
          PYK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          PYK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          PYK2 Antibody (PA5-82904) in IHC (P)

          Immunohistochemical analysis of PYK2 in human cerebral cortex using PYK2 Polyclonal Antibody (Product # PA5-82904) shows strong nuclear positivity in neuronal cells. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
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          PYK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          PYK2 Antibody in Western Blot (WB)
          PYK2 Antibody in Western Blot (WB)
          PYK2 Antibody
          PYK2 Polyclonal Antibody

          Product Details

          PA5-82904

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.04-0.4 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:50
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein corresponding to Human PTK2B. Recombinant protein control fragment (Product #RP-95203).
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 40% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2790060

          Product Specific Information

          Immunogen sequence: TLTSPMEYPS PVNSLHTPPL HRHNVFKRHS MREEDFIQPS SREEAQQLWE AEKVKMRQIL DKQQKQMVED YQWLRQEEKS LDPM

          Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 90%.

          Target Information

          PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: CADTK; CAK beta; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; FRNK; pp125FAK; Proline-rich tyrosine kinase 2; protein kinase B; Protein-tyrosine kinase 2-beta; PTK2 protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase; unnamed protein product

          View more View less

          Gene Aliases: CADTK; CAKB; CAKbeta; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK

          View more View less

          UniProt ID: (Human) Q14289, (Rat) P70600

          View more View less

          Entrez Gene ID: (Human) 2185, (Rat) 50646

          View more View less

          Function(s)
          nucleotide binding protein kinase activity calmodulin-dependent protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity receptor activator activity ionotropic glutamate receptor binding neurotransmitter receptor regulator activity NMDA glutamate receptor activity receptor binding protein complex binding 3-phosphoinositide-dependent protein kinase binding
          Process(es)
          MAPK cascade response to reactive oxygen species angiogenesis oocyte maturation response to hypoxia positive regulation of cell-matrix adhesion sprouting angiogenesis marginal zone B cell differentiation protein phosphorylation cellular defense response response to osmotic stress actin filament organization cell adhesion cell surface receptor signaling pathway signal complex assembly epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus response to hormone response to glucose response to lithium ion response to organonitrogen compound positive regulation of endothelial cell migration negative regulation of muscle cell apoptotic process regulation of cGMP-mediated signaling regulation of macrophage chemotaxis positive regulation of neuron projection development glial cell proliferation peptidyl-tyrosine phosphorylation cell differentiation regulation of cell adhesion negative regulation of ossification positive regulation of cell growth positive regulation of cell migration negative regulation of bone mineralization regulation of cGMP biosynthetic process positive regulation of actin filament polymerization neuron projection development regulation of inositol trisphosphate biosynthetic process tumor necrosis factor-mediated signaling pathway ionotropic glutamate receptor signaling pathway response to immobilization stress peptidyl-tyrosine autophosphorylation response to cocaine response to drug response to hydrogen peroxide activation of Janus kinase activity negative regulation of apoptotic process stress fiber assembly negative regulation of potassium ion transport positive regulation of JUN kinase activity negative regulation of neuron apoptotic process blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of nitric oxide biosynthetic process bone resorption response to ethanol negative regulation of myeloid cell differentiation positive regulation of translation positive regulation of angiogenesis positive regulation of protein kinase activity positive regulation of JNK cascade vascular endothelial growth factor receptor signaling pathway focal adhesion assembly positive regulation of peptidyl-tyrosine phosphorylation regulation of calcium-mediated signaling positive regulation of nitric-oxide synthase activity regulation of release of sequestered calcium ion into cytosol response to cAMP response to calcium ion positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to fluid shear stress activation of GTPase activity regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of establishment of cell polarity regulation of actin cytoskeleton reorganization regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of reactive oxygen species metabolic process positive regulation of excitatory postsynaptic potential positive regulation of B cell chemotaxis neuron migration regulation of cell-matrix adhesion adaptive immune response immune system process apoptotic process cytoskeleton organization Golgi organization signal transduction positive regulation of signal transduction cortical cytoskeleton organization regulation of actin cytoskeleton organization protein autophosphorylation regulation of synaptic plasticity regulation of multicellular organismal process positive regulation of protein kinase B signaling protein-containing complex assembly endothelin receptor signaling pathway regulation of postsynaptic density assembly
          It has to be done as per old AB suggested Products section.

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