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Invitrogen
Kir1.1 (KCNJ1) Polyclonal Antibody
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Product Details
PA5-82946
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCNJ1. Recombinant protein control fragment (Product #RP-90994).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: STSATCQVRT SYVPEEVLWG YRFAPIVSKT KEGKYRVDFH NFSKTVEVET PHCAMCLYNE KDVRARMKRG YDNPNFILSE VNETD
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 93%.
Target Information
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; OTTHUMP00000045938; Potassium channel, inwardly rectifying subfamily J member 1; potassium voltage-gated channel subfamily J member 1; unnamed protein product
Gene Aliases: KCNJ1; KIR1.1; ROMK; ROMK1
UniProt ID: (Human) P48048
Entrez Gene ID: (Human) 3758
kidney development
tissue homeostasis
ion transport
potassium ion transport
post-embryonic development
gene expression
metal ion transport
ion transmembrane transport
regulation of ion transmembrane transport
renal sodium ion absorption
circulatory system development
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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