Search
Invitrogen
HTRA2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-82969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HTRA2. Recombinant protein control fragment (Product #RP-89255).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSR
Highest antigen sequence indentity to the following orthologs: Rat - 63%, Mouse - 57%.
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; High temperature requirement protein A2; HtrA-like serine protease; HtrA2; Omi; Omi stress-regulated endoprotease; protease, serine, 25; Serine protease 25; Serine protease HTRA2, mitochondrial; Serine proteinase OMI; unnamed protein product
Gene Aliases: HTRA2; MGCA8; OMI; PARK13; PRSS25
UniProt ID: (Human) O43464
Entrez Gene ID: (Human) 27429
proteolysis
ceramide metabolic process
apoptotic process
mitochondrion organization
adult walking behavior
adult locomotory behavior
intrinsic apoptotic signaling pathway in response to DNA damage
response to herbicide
programmed cell death
protein autoprocessing
pentacyclic triterpenoid metabolic process
protein catabolic process
forebrain development
cellular response to oxidative stress
cellular response to heat
cellular response to interferon-beta
intracellular signal transduction
mitochondrial protein catabolic process
regulation of multicellular organism growth
positive regulation of apoptotic process
negative regulation of neuron apoptotic process
negative regulation of cell cycle
neuron development
neuron apoptotic process
cellular response to retinoic acid
cellular response to growth factor stimulus
intrinsic apoptotic signaling pathway
execution phase of apoptosis
positive regulation of execution phase of apoptosis
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support