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Invitrogen
AP2 alpha Polyclonal Antibody
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Product Details
PA5-83036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TFAP2A. Recombinant protein control fragment (Product #RP-94906).
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RHEDLLHGPH ALSSGLGDLS IHSLPHAIEE VPHVEDPGIN IPDQTVIKKG PVSLSKSNSN AVSAIPINKD
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating enhancer-binding protein 2 alpha; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 transcription factor; AP2-alpha; DNA-binding protein (AP-2); ERF-1; FLJ51761; OTTHUMP00000214240; OTTHUMP00000214243; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha; unnamed protein product
Gene Aliases: AP-2; AP-2alpha; AP2TF; BOFS; Tcfap2a; TFAP2; TFAP2A
UniProt ID: (Human) P05549
Entrez Gene ID: (Human) 7020, (Rat) 306862
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
transcription coactivator activity
transcription factor binding
transcription regulatory region DNA binding
protein dimerization activity
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
kidney development
optic vesicle morphogenesis
optic cup structural organization
regulation of transcription, DNA-templated
nervous system development
sensory perception of sound
negative regulation of cell proliferation
positive regulation of gene expression
retina layer formation
negative regulation of transcription by competitive promoter binding
trigeminal nerve development
oculomotor nerve formation
positive regulation of bone mineralization
embryonic forelimb morphogenesis
regulation of cell proliferation
inner ear morphogenesis
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
palate development
bone morphogenesis
eyelid development in camera-type eye
positive regulation of tooth mineralization
cellular response to iron ion
negative regulation of reactive oxygen species metabolic process
neural tube closure
lens morphogenesis in camera-type eye
outflow tract morphogenesis
keratinocyte development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
response to water deprivation
embryonic pattern specification
response to organic substance
embryonic body morphogenesis
neural crest cell development
Schwann cell development
anterior neuropore closure
forebrain neuron development
positive regulation of cell migration
response to lipopolysaccharide
forelimb morphogenesis
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of neuron apoptotic process
skin development
regulation of neuron differentiation
sympathetic nervous system development
embryonic camera-type eye morphogenesis
skeletal system morphogenesis
epidermis morphogenesis
lens induction in camera-type eye
face morphogenesis
cornea development in camera-type eye
basement membrane organization
metanephric nephron development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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