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Invitrogen
PIP5K1A Polyclonal Antibody
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Product Details
PA5-83084
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PIP5K1A. Recombinant protein control fragment (Product #RP-89191).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KRRASQKERE KPLPTFKDLD FLQDIPDGLF LDADMYNALC KTLQRDCLVL QSFKIMDYSL LMSIHNIDHA QREPLSSETQ YSVDTRRPAP QKALYSTAME SIQGEARRGG TMETDDHMGG IPAR
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 93%.
Target Information
PIP5K1A lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through 'frizzled' and 'disheveled', the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP(2) production and enhances viral replication in primary lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase; PI51A; PIP5K1-alpha; PIP5KIalpha; ptdIns(4)P-5-kinase 1 alpha; unnamed protein product
Gene Aliases: PIP5K1A
UniProt ID: (Human) Q99755
Entrez Gene ID: (Human) 8394
lipid metabolic process
glycerophospholipid metabolic process
phosphatidylinositol biosynthetic process
phagocytosis
signal transduction
phospholipid biosynthetic process
fibroblast migration
cell migration
actin cytoskeleton organization
keratinocyte differentiation
phosphatidylinositol metabolic process
phosphatidylinositol phosphorylation
focal adhesion assembly
regulation of protein kinase B signaling
cell chemotaxis
protein localization to plasma membrane
activation of GTPase activity
ruffle assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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