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Invitrogen
TLX3 Polyclonal Antibody
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Product Details
PA5-83146
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TLX3. Recombinant protein control fragment (Product #RP-108335).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: APFEDAGSYS VNLSLAPAGV IRVPAHRPLP GAVPPPLPSA LPAMPSVPTV SSLGGLNFPW MESSRRFVKD RFTA
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 11-like 2; homeobox 11-like 2; Homeobox protein Hox-11L2; T-cell leukemia homeobox protein 3
Gene Aliases: HOX11L2; RNX; TLX3
UniProt ID: (Human) O43711
Entrez Gene ID: (Human) 30012
neuron migration
regulation of respiratory gaseous exchange by neurological system process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
central nervous system development
respiratory gaseous exchange
neuron differentiation
negative regulation of neuron differentiation
animal organ development
neuron fate specification
GABAergic neuron differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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