Invitrogen

ZC3H12A Polyclonal Antibody

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ZC3H12A Polyclonal Antibody

Product Details

PA5-83215

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZC3H12A. Recombinant protein control fragment (Product #RP-94438).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790371

Product Specific Information

Immunogen sequence: AFPPREYWSE PYPLPPPTSV LQEPPVQSPG AGRSPWGRAG SLAKEQASVY TKLCGVFPPH LVEAVMGRFP QLLDPQQLAA EILSYKSQHP S

Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 84%.

Target Information

ZC3H12A is an MCP1 -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Endoribonuclease ZC3H12A; MCP-1 treatment-induced protein; MCP-induced protein 1; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; ribonuclease ZC3H12A; RP3-423B22.1; Zinc finger CCCH domain-containing protein 12A

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Gene Aliases: dJ423B22.1; MCPIP; MCPIP1; ZC3H12A

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UniProt ID: (Human) Q5D1E8

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Entrez Gene ID: (Human) 80149

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Function(s)
DNA binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding endoribonuclease activity exoribonuclease activity ribonuclease activity thiol-dependent ubiquitin-specific protease activity protein binding miRNA binding RNA stem-loop binding mRNA 3'-UTR AU-rich region binding ribosome binding metal ion binding endoribonuclease
Process(es)
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay angiogenesis negative regulation of protein phosphorylation positive regulation of defense response to virus by host transcription, DNA-templated apoptotic process inflammatory response cellular response to DNA damage stimulus nervous system development regulation of gene expression positive regulation of autophagy positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of lipid storage positive regulation of cell death protein deubiquitination cell differentiation negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production cellular response to oxidative stress cellular response to glucose starvation positive regulation of protein import into nucleus negative regulation of NF-kappaB import into nucleus negative regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral genome replication negative regulation of nitric oxide biosynthetic process positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter negative regulation of interleukin-1 beta secretion protein oligomerization defense response to virus negative regulation of cardiac muscle contraction positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic RNA phosphodiester bond hydrolysis, exonucleolytic cellular response to virus negative regulation of cytokine production involved in inflammatory response positive regulation of execution phase of apoptosis negative regulation of interleukin-6 secretion positive regulation of p38MAPK cascade negative regulation of interferon-gamma secretion positive regulation of protein deubiquitination negative regulation of production of miRNAs involved in gene silencing by miRNA cellular response to sodium arsenite negative regulation of tumor necrosis factor secretion cellular response to phorbol 13-acetate 12-myristate cellular response to ionomycin cellular response to chemokine positive regulation of reactive oxygen species metabolic process positive regulation of miRNA catabolic process
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