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Invitrogen
Ankyrin B Polyclonal Antibody
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Product Details
PA5-83300
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ANK2. Recombinant protein control fragment (Product #RP-102424).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DGVPKTEGDS SATALFPQTH KEQVQQDFSG KMQDLPEESS LEYQQEYFVT TPGTETSETQ KAMIVPSSPS KTPEEVSTPA EEEKLYLQTP TSSERGGSPI IQEPEEPSEH REESSPRKTS LVIVESADNQ PETCERLDED AAFE
Highest antigen sequence indentity to the following orthologs: Rat - 64%, Mouse - 65%.
Target Information
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-2; ankyrin 2, neuronal; ankyrin B; ankyrin, brain; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin; unnamed protein product
Gene Aliases: ANK-2; ANK2; ANKB; brank-2; CFAP87; FAP87; LQT4
UniProt ID: (Human) Q01484
Entrez Gene ID: (Human) 287
structural constituent of cytoskeleton
protein binding
cytoskeletal adaptor activity
enzyme binding
protein kinase binding
spectrin binding
protein binding, bridging
ion channel binding
ATPase binding
channel activator activity
potassium channel activator activity
phosphorylation-dependent protein binding
regulation of heart rate
atrial septum development
cellular calcium ion homeostasis
endocytosis
cytoskeleton organization
signal transduction
nervous system development
protein localization
positive regulation of gene expression
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
protein transport
paranodal junction assembly
regulation of protein stability
T-tubule organization
protein localization to cell surface
protein localization to M-band
protein localization to T-tubule
protein stabilization
regulation of release of sequestered calcium ion into cytosol
response to methylmercury
regulation of calcium ion transport
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
sarcoplasmic reticulum calcium ion transport
protein localization to endoplasmic reticulum
protein localization to plasma membrane
regulation of cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
atrial cardiac muscle cell action potential
SA node cell action potential
membrane depolarization during SA node cell action potential
atrial cardiac muscle cell to AV node cell communication
SA node cell to atrial cardiac muscle cell communication
regulation of heart rate by cardiac conduction
regulation of SA node cell action potential
regulation of atrial cardiac muscle cell action potential
positive regulation of potassium ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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