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Invitrogen
LATS2 Polyclonal Antibody
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Product Details
PA5-83451
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LATS2. Recombinant protein control fragment (Product #RP-97249).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HLLLRSKSEQ YDLDSLCAGM EQSLRAGPNE PEGGDKSRKS AKGDKGGKDK KQIQTSPVPV RKNSRDEEKR
Highest antigen sequence indentity to the following orthologs: Mouse - 75%, Rat - 74%.
Target Information
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. LATS2 plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h-warts; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2; serine/threonine kinase KPM; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; unnamed protein product; Warts-like kinase
Gene Aliases: KPM; LATS2
UniProt ID: (Human) Q9NRM7
Entrez Gene ID: (Human) 26524
G1/S transition of mitotic cell cycle
inner cell mass cell fate commitment
inner cell mass cellular morphogenesis
protein phosphorylation
protein localization
hormone-mediated signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
keratinocyte differentiation
hippo signaling
positive regulation of hippo signaling
intracellular signal transduction
positive regulation of apoptotic process
mitotic cell cycle phase transition
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of organ growth
cell division
canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
negative regulation of protein localization to nucleus
positive regulation of NLRP3 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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